IPM - Brain Engineering Center


Seminar - May 25, 2016

Hyperthermia of Magnetic Nanoparticles and the Blood-Brain Barrier
Wednesday, May 25, 2016 (15:00 - 17:00)
Dr. Seyed Nasrollah Tabatabaie
CHU Sainte-Justine, Montréal

Despite advances in neurology, drug delivery to the brain remains a substantial challenge. This is mainly due to the insurmountable and selective nature of the blood–brain barrier (BBB). In this study, we show that the thermal energy generated by magnetic heating (hyperthermia) of commercially available magnetic nanoparticles (MNPs) in the brain capillaries of rats can transiently increase barrier permeability. Here, the fluorescent Evans Blue (EB) dye was used to verify the BBB integrity. Results indicate a substantial but reversible opening of the BBB where hyperthermia is applied. Also, in this investigation, analysis of CD68 immunoreactivity, an indicator of inflammation, implies that this technique is not associated with any inflammation. We have previously investigated theranostic (therapeutic and diagnostic) capabilities of the MNPs, therefore, the findings presented in this investigation are particularly encouraging for a novel targeted drug delivery system to the brain.

The seminar will be held at the conference room of Particles and Accelerators school, IPM, Larak, Tehran


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